123操逼网【學術預告】Reactive Protein - Proteome Profiling “RP3”∏, a chemical ap伦伦影院proach to Fic-tox手機AVin substrate identification-南京師範大學
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學術預告

【學術預告】Reactive Protein - Proteome Profiling “RP3”■, a chemical approach to Fic-toxin substrate identification

化行樓224

報告題目就要魯㊣:Reactive Protein - Proteome Profiling “RP3”♀, a chemical approach to Fic-toxin substrate identification深愛成人網

報告人中文字幕免費【福利視頻】↘:Prof. Dr. Christian Hedberg啪啪免費觀看大全av

工作單位黃色視頻做爰視頻↘:Institute of Chemistry■, Umeå University≡, Sweden成年人片

時間日本無碼高清中文視頻〗㊣:11月28日(星期四)上午10:00-11:00日本視頻一區在線播放

聯係人日本邪惡漫畫動態圖〗㊣:錢勇HD美女D

邀請單位2018在線國產偷拍視〗㊣:化學與材料科學學院色和尚成人視頻

地點他也色他也色視頻〗㊣:化行樓224自拍區偷拍亞洲歐美

簡介國外色幼網〗㊣:青娛樂國產視頻盛

Abstract:This presentation covers a new method denotedReactiveProtein -ProteomeProfilingRP3”.We have created a robust workflow for absolute substrate profiling of bacterial toxins against cellular target proteins employing covalent nucleotide co-substrates resulting in covalent ternary complexes. During infection▲〓, pathogenic bacteria tweak their eukaryotic hosts by translocating toxins. Toxins display catalytic activity against host cell proteins♂╳, targeting key functions∏█, often using an abundant metabolite as co-substrate.No tools exist for the proteomic evaluation of the absolute substrate profile of a given toxin.Non-covalent affinity enrichment gives biased results depending on the reagent and relative target abundance. Our concept is based on covalent and subsequently cleavable capture of the target proteins by the reactive co-substrate of the toxin. Mutants (X to C) in the nucleotide-binding pocket of the toxin IbpA (H. somni)were modified with ATP-analogues carrying an electrophile. The binary complex forms the ternary complex with the IbpA-substrate cdc42in vitro. A number of other toxins belonging to the Fic-class have been profiled. For ADP-ribosylation〓, Pertussis toxin captures Giain vitrousing NAD+analogues. Altogether◣←, this suggests that the RP3concept is valid and practicable.The project is highly significant for the infection biology field in terms of profiling toxins▼, but also to the chemical biology community☆卐, by moving ABPP to macromolecules via RP3.777電影網

報告人簡介戀足視頻↘:Bengt Christian Hedberg博士青娛樂在線▽,2005年獲瑞典烏普薩拉大學有機化學博士超碰在線視頻97√◤。2008-2014擔任德國馬克斯普朗克分子生理學研究所化學生物學係Max-Planck研究組長開心激情站▽,2014-至今擔任瑞典於默奧大學化學研究所生物有機化學教授色先鋒影音看片∩→。2013年入選瑞典皇家科學院青年院士(Wallenberg Academy Fellow)米奇777午夜影院◥,近五年已在PNAS光棍電影█︽,Angewandte Chemie老司機下載的直播app∮【,Biophysical Journal倫理片↘ζ ,Journal of Organic Chemistry擼擼鳥★,Organic Letters等期刊發表論文15餘篇爽啦娛樂網〗@。男人天堂2019新在線版

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